LF15-0195 generates tolerogenic dendritic cells by suppression of NF-kappaB signaling through inhibition of IKK activity.

@article{Yang2003LF150195GT,
  title={LF15-0195 generates tolerogenic dendritic cells by suppression of NF-kappaB signaling through inhibition of IKK activity.},
  author={Jinming Yang and Suzanne M. Bernier and Thomas E. Ichim and Mu J Li and Xiaoping Xia and Dejun Zhou and Xuyan Huang and Gill H Strejan and David J White and Robert Zhong and Weiping Min},
  journal={Journal of leukocyte biology},
  year={2003},
  volume={74 3},
  pages={438-47}
}
LF15-0195 (LF) is a potent, less toxic analog of the immunosuppressant 15-deoxyspergualine, which we previously reported to prevent graft rejection and to induce permanent tolerance in a murine cardiac transplantation model. However, the underlying mechanism of action of LF required elucidation. In this study, dendritic cells (DC) treated with LF before activation with tumor necrosis factor alpha (TNF-alpha)/lipopolysaccharide (LPS) failed to express maturation markers (major histocompatibility… CONTINUE READING

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