LEW.1WR1 rats develop autoimmune diabetes spontaneously and in response to environmental perturbation.

@article{Mordes2005LEW1WR1RD,
  title={LEW.1WR1 rats develop autoimmune diabetes spontaneously and in response to environmental perturbation.},
  author={John P. Mordes and Dennis L. Guberski and Jean H. Leif and Bruce A. Woda and Joan F. Flanagan and Dale L. Greiner and E. Kislauskis and Rebecca S. Tirabassi},
  journal={Diabetes},
  year={2005},
  volume={54 9},
  pages={2727-33}
}
We describe a new rat model of autoimmune diabetes that arose in a major histocompatibility complex congenic LEW rat. Spontaneous diabetes in LEW.1WR1 rats (RT1(u/u/a)) occurs with a cumulative frequency of approximately 2% at a median age of 59 days. The disease is characterized by hyperglycemia, glycosuria, ketonuria, and polyuria. Both sexes are affected, and islets of acutely diabetic rats are devoid of beta-cells, whereas alpha- and delta-cell populations are spared. The peripheral… CONTINUE READING
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