LEW.1WR1 rats develop autoimmune diabetes spontaneously and in response to environmental perturbation.

  title={LEW.1WR1 rats develop autoimmune diabetes spontaneously and in response to environmental perturbation.},
  author={John P. Mordes and Dennis L. Guberski and Jean H. Leif and Bruce A. Woda and Joan F. Flanagan and Dale L. Greiner and E. Kislauskis and Rebecca S. Tirabassi},
  volume={54 9},
We describe a new rat model of autoimmune diabetes that arose in a major histocompatibility complex congenic LEW rat. Spontaneous diabetes in LEW.1WR1 rats (RT1(u/u/a)) occurs with a cumulative frequency of approximately 2% at a median age of 59 days. The disease is characterized by hyperglycemia, glycosuria, ketonuria, and polyuria. Both sexes are affected, and islets of acutely diabetic rats are devoid of beta-cells, whereas alpha- and delta-cell populations are spared. The peripheral… CONTINUE READING
20 Citations
53 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 20 extracted citations


Publications referenced by this paper.
Showing 1-10 of 53 references

Associations between immune-mediated LEW.1WR1 RATS AND AUTOIMMUNE DIABETES

  • S Ten, A Kukreja, N Maclaren
  • 2005

( Abstract )

  • DL Guberski, VA Thomas, +5 authors RM Welsh
  • 2004

Guberski DL: Rat strain specific susceptibility to environmental induction of type 1 diabetes (Abstract)

  • RS Tirabassi, JF Flanagan, EH Kislauskis, JP Mordes, DL Greiner, JH Leif
  • Diabetes 53 (Suppl
  • 2004

Effects of insulin in relatives of patients with type 1 diabetes mellitus

  • JS Skyler, D Brown, +21 authors JI Malone
  • N Engl J Med 346:1685–1691,
  • 2002

Similar Papers

Loading similar papers…