LET-767 is required for the production of branched chain and long chain fatty acids in Caenorhabditis elegans.

@article{Entchev2008LET767IR,
  title={LET-767 is required for the production of branched chain and long chain fatty acids in Caenorhabditis elegans.},
  author={Eugeni V. Entchev and Dominik Schwudke and Vyacheslav Zagoriy and Vitali Matyash and Aliona Bogdanova and Bianca H Habermann and Lin Zhu and Andrej Shevchenko and Teymuras V Kurzchalia},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 25},
  pages={17550-60}
}
LET-767 from Caenorhabditis elegans belongs to a family of short chain dehydrogenases/reductases and is homologous to 17beta-hydroxysterol dehydrogenases of type 3 and 3-ketoacyl-CoA reductases. Worms subjected to RNA interference (RNAi) of let-767 displayed multiple growth and developmental defects in the first generation and arrested in the second generation as L1 larvae. To determine the function of LET-767 in vivo, we exploited a biochemical complementation approach, in which let-767 (RNAi… CONTINUE READING