LEPR gene polymorphisms: associations with overweight, fat mass and response to diet in women.

@article{Mamms2001LEPRGP,
  title={LEPR gene polymorphisms: associations with overweight, fat mass and response to diet in women.},
  author={Olivier Mamm{\`e}s and Roberte Aubert and Dina Betoulle and Frank P{\'e}an and Bernard Herbeth and Sophia Visvikis and G{\'e}rard Siest and Fr{\'e}d{\'e}ric Fumeron},
  journal={European journal of clinical investigation},
  year={2001},
  volume={31 5},
  pages={398-404}
}
BACKGROUND In humans, a mutation of the leptin receptor gene (LEPR) leads to a rare obese syndrome of mendelian inheritance. However, obesity in humans results from interactions between genes and environment, mainly nutritional factors. Variations at the LEPR locus could be involved in the regulation of body weight. DESIGN Genetic variations at the LEPR locus were screened in a selection of 30 French overweight subjects by Single Strand Conformation Polymorphism (SSCP) analysis, then an… CONTINUE READING

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