LEM-3 – A LEM Domain Containing Nuclease Involved in the DNA Damage Response in C. elegans

  title={LEM-3 – A LEM Domain Containing Nuclease Involved in the DNA Damage Response in C. elegans},
  author={Christina M. Dittrich and Katja Kratz and Ataman Sendoel and Yosef Gruenbaum and Josef Jiricny and Michael O. Hengartner},
  booktitle={PloS one},
The small nematode Caenorhabditis elegans displays a spectrum of DNA damage responses similar to humans. In order to identify new DNA damage response genes, we isolated in a forward genetic screen 14 new mutations conferring hypersensitivity to ionizing radiation. We present here our characterization of lem-3, one of the genes identified in this screen. LEM-3 contains a LEM domain and a GIY nuclease domain. We confirm that LEM-3 has DNase activity in vitro. lem-3(lf) mutants are hypersensitive… CONTINUE READING
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