LEKTI: a multidomain serine proteinase inhibitor with pathophysiological relevance.

@article{Mgert2002LEKTIAM,
  title={LEKTI: a multidomain serine proteinase inhibitor with pathophysiological relevance.},
  author={Hans J{\"u}rgen M{\"a}gert and Peter Kreutzmann and Ludger Staendker and Michael R. Walden and Katrin Dr{\"o}gem{\"u}ller and Wolf Georg Forssmann},
  journal={The international journal of biochemistry & cell biology},
  year={2002},
  volume={34 6},
  pages={573-6}
}
Proteinase inhibitors are important negative regulators of proteinase action in vivo and are thus involved in several pathophysiological processes. Starting with the isolation of two new peptides from human blood filtrate, we succeeded in cloning a cDNA encoding the precursor protein for a novel 15-domain Kazal-type-related serine proteinase inhibitor. Two of the 15 domains almost exactly match the Kazal-type pattern, whereas the other 13 domains exhibit only four instead of six cysteine… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 15 references

Y

  • S. Chavanas, C. Bodemer, +8 authors J. I. Harper
  • de Prost, A. Hovnanian, Mutations in SPINK5…
  • 2000
Highly Influential
4 Excerpts

Localization of the Netherton syndrome gene to chromosome 5 q 32 , by linkage analysis and homozygosity mapping

  • C. Garner S. Chavanas, C. Bodemer, +14 authors A. Hovnanian
  • Am . J . Hum . Genet .
  • 2000

Lekti

  • H.-J. Mägert, L. Ständker, +5 authors W.-G. Forssmann
  • a novel 15-domain type of human serine proteinase…
  • 1999
2 Excerpts

Similar Papers

Loading similar papers…