LEF1 is preferentially expressed in the tubal-peritoneal junctions and is a reliable marker of tubal intraepithelial lesions

@inproceedings{Schmoeckel2017LEF1IP,
  title={LEF1 is preferentially expressed in the tubal-peritoneal junctions
and is a reliable marker of tubal intraepithelial lesions},
  author={Elisa Schmoeckel and Ashley A. Odai-Afotey and Michael Schlei{\ss}heimer and Miriam Rottmann and Andrea Flesken-Nikitin and Lora Hedrick Ellenson and Tom Kirchner and Doris Mayr and Alexander Yu Nikitin},
  booktitle={Modern Pathology},
  year={2017}
}
Recently it has been reported that serous tubal intraepithelial carcinoma (STIC), the likely precursor of ovarian/extra-uterine high-grade serous carcinoma, are frequently located in the vicinity of tubal-peritoneal junctions, consistent with the cancer-prone features of many epithelial transitional regions. To test if p53 (aka TP53)-signatures and secretory cell outgrowths (SCOUTs) also localize to tubal-peritoneal junctions, we examined these lesions in the fallopian tubes of patients… CONTINUE READING
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