LEF-AS1 participates in occurrence of colorectal cancer through adsorbing miR-505 and promoting KIF3B expression.

@article{Gong2019LEFAS1PI,
  title={LEF-AS1 participates in occurrence of colorectal cancer through adsorbing miR-505 and promoting KIF3B expression.},
  author={Xuyang Gong and A-L Huang},
  journal={European review for medical and pharmacological sciences},
  year={2019},
  volume={23 21},
  pages={
          9362-9370
        }
}
  • Xuyang Gong, A-L Huang
  • Published 2019
  • Chemistry, Medicine
  • European review for medical and pharmacological sciences
OBJECTIVE To explore the possible role and mechanism of long non-coding ribonucleic acid LEF-AS1 (lncRNA LEF-AS1) in the pathogenesis of colorectal cancer (CRC). PATIENTS AND METHODS The expression levels of LEF-AS1 in 54 CRC tissue samples and adjacent normal ones were examined by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). In the meantime, CRC cell lines were screened for subsequent in vitro experiments. LEF-AS1 siRNA was transfected into CRC cells using the liposome method… Expand