LEDGF regulation of alcohol and aldehyde dehydrogenases in lens epithelial cells: stimulation of retinoic acid production and protection from ethanol toxicity.

@article{Fatma2004LEDGFRO,
  title={LEDGF regulation of alcohol and aldehyde dehydrogenases in lens epithelial cells: stimulation of retinoic acid production and protection from ethanol toxicity.},
  author={Nigar Fatma and Eri Kubo and Leo T. Chylack and Toshimichi Shinohara and Yoshio Akagi and Dhirendra Pratap Singh},
  journal={American journal of physiology. Cell physiology},
  year={2004},
  volume={287 2},
  pages={
          C508-16
        }
}
Retinoic acid (RA) is required for the normal growth and maintenance of many cell types, including lens epithelial cells (LECs). Alcohol (ADH) and aldehyde (ALDH) dehydrogenases are implicated in cellular detoxification and conversion of vitamin A to RA. Lens epithelium-derived growth factor (LEDGF) provides cellular protection against stress by transactivating stress-associated genes. Here we show evidence that LEDGF binds and transactivates heat shock (nGAAn) and stress response (A/TGGGGA/T… 
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Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily.
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What is currently known about each member of the human ALDH superfamily, composed of NAD(P)+-dependent enzymes that catalyze aldehyde oxidation, is presented including the pathophysiological significance of these enzymes.
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