LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes.

@article{Llano2004LEDGFp75DC,
  title={LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes.},
  author={Manuel Llano and Maria E Vanegas and Oliver I. Fregoso and Dyana Saenz and Susan H. Chung and Mary Peretz and Eric M. Poeschla},
  journal={Journal of virology},
  year={2004},
  volume={78 17},
  pages={9524-37}
}
Human immunodeficiency virus type 1 (HIV-1), feline immunodeficiency virus (FIV), and Moloney murine leukemia virus (MoMLV) integrases were stably expressed to determine their intracellular trafficking. Each lentiviral integrase localized to cell nuclei in close association with chromatin while the murine oncoretroviral integrase was cytoplasmic. Fusions of pyruvate kinase to the lentiviral integrases did not reveal transferable nuclear localization signals. The intracellular trafficking of… CONTINUE READING