LDLs stimulate p38 MAPKs and wound healing through SR-BI independently of Ras and PI3 kinase.

@article{Bulat2009LDLsSP,
  title={LDLs stimulate p38 MAPKs and wound healing through SR-BI independently of Ras and PI3 kinase.},
  author={Natasa Bulat and G{\'e}rard Waeber and Christian Widmann},
  journal={Journal of lipid research},
  year={2009},
  volume={50 1},
  pages={81-9}
}
Intracellular signals elicited by LDLs are likely to play a role in the pathogenesis associated with increased LDL blood levels. We have previously determined that LDL stimulation of human skin fibroblasts, used as a model system for adventitial fibroblasts, activates p38 mitogen-activated protein kinases (MAPKs), followed by IL-8 production and increased wound-healing capacity of the cells. The proximal events triggering these responses had not been characterized, however. Here we show that… CONTINUE READING