LDLR-mediated peptide-22-conjugated nanoparticles for dual-targeting therapy of brain glioma.

@article{Zhang2013LDLRmediatedPN,
  title={LDLR-mediated peptide-22-conjugated nanoparticles for dual-targeting therapy of brain glioma.},
  author={Bo Zhang and Xiyang Sun and Heng Mei and Yu Wang and Ziwei Liao and Jun Chen and Qizhi Zhang and Yu Cheng Hu and Zhiqing Pang and Xinguo Jiang},
  journal={Biomaterials},
  year={2013},
  volume={34 36},
  pages={9171-82}
}
Chemotherapy for brain glioma has been of limited benefit due to the inability of drugs to penetrate the blood-brain barrier (BBB) and non-selective drug accumulation in the entire brain. To obviate these limitations, dual-targeting paclitaxel-loaded nanoparticles were developed by decoration with peptide-22 (PNP-PTX), a peptide with special affinity for low-density lipoprotein receptor (LDLR), to transport the drug across the BBB, and then target brain tumour cells. Enzyme-linked immune… CONTINUE READING