LDL-receptor-related protein 6 is a receptor for Dickkopf proteins

  title={LDL-receptor-related protein 6 is a receptor for Dickkopf proteins},
  author={Bingyu Mao and Wei Wu and Yan Li and Dana Hoppe and Peter Stannek and Andrei Glinka and Christof Niehrs},
Wnt glycoproteins have been implicated in diverse processes during embryonic patterning in metazoa. They signal through frizzled-type seven-transmembrane-domain receptors to stabilize β-catenin. Wnt signalling is antagonized by the extracellular Wnt inhibitor dickkopf1 (dkk1), which is a member of a multigene family. dkk1 was initially identified as a head inducer in Xenopus embryos but the mechanism by which it blocks Wnt signalling is unknown. LDL-receptor-related protein 6 (LRP6) is required… CONTINUE READING