LDL oxidation by arterial wall macrophages depends on the oxidative status in the lipoprotein and in the cells: Role of prooxidants vs. antioxidants

@article{Aviram2004LDLOB,
  title={LDL oxidation by arterial wall macrophages depends on the oxidative status in the lipoprotein and in the cells: Role of prooxidants vs. antioxidants},
  author={M. Aviram and B. Fuhrman},
  journal={Molecular and Cellular Biochemistry},
  year={2004},
  volume={188},
  pages={149-159}
}
Oxidized LDL is highly atherogenic as it stimulates macrophage cholesterol accumulation and foam cell formation, it is cytotoxic to cells of the arterial wall and it stimulates inflammatory and thrombotic processes. LDL oxidation can lead to its subsequent aggregation, which further increases cellular cholesterol accumulation.All major cells in the arterial wall including endothelial cells, smooth muscle cells and monocyte derived macrophages can oxidize LDL. Macrophage-mediated oxidation of… Expand
Platelet lipoprotein interplay: trigger of foam cell formation and driver of atherosclerosis.
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