LDL-lipids from patients with hypercholesterolaemia and Alzheimer's disease are inflammatory to microvascular endothelial cells: mitigation by statin intervention.

@article{Dias2015LDLlipidsFP,
  title={LDL-lipids from patients with hypercholesterolaemia and Alzheimer's disease are inflammatory to microvascular endothelial cells: mitigation by statin intervention.},
  author={H K I Dias and Caroline L R Brown and Maria Cristina Polidori and Gregory Y. H. Lip and Helen R Griffiths},
  journal={Clinical science},
  year={2015},
  volume={129 12},
  pages={1195-206}
}
Elevated low-density lipoprotein (LDL) concentration in mid-life increases the risk of developing Alzheimer's disease (AD) in later life. Increased oxidized LDL (oxLDL) modification and nitration is observed during dementia and hypercholesterolaemia. We investigated the hypothesis that statin intervention in mid-life mitigates the inflammatory effects of oxLDL on the microvasculature. Human microvascular endothelial cells (HMVECs) were maintained in transwells to mimic the microvasculature and… CONTINUE READING