LDL immunization induces T-cell-dependent antibody formation and protection against atherosclerosis.

@article{Zhou2001LDLII,
  title={LDL immunization induces T-cell-dependent antibody formation and protection against atherosclerosis.},
  author={Xinghua Zhou and Giuseppina Caligiuri and Anders Hamsten and Ann Kari Lefvert and G{\"o}ran K. Hansson},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2001},
  volume={21 1},
  pages={108-14}
}
Atherosclerosis is an inflammatory disease, and the involvement of immune mechanisms in disease progression is increasingly recognized. Immunization with oxidized low density lipoprotein (LDL) decreases atherosclerosis in several animal models. To explore humoral and cellular immune reactions involved in this protection, we immunized apolipoprotein E knockout mice with either homologous plaque homogenates or homologous malondialdehyde (MDA)-LDL. Immunization with both these antigen preparations… CONTINUE READING
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