LDL Cholesterol Modulates Human CD34+ HSPCs through Effects on Proliferation and the IL-17 G-CSF Axis

@inproceedings{Cimato2013LDLCM,
  title={LDL Cholesterol Modulates Human CD34+ HSPCs through Effects on Proliferation and the IL-17 G-CSF Axis},
  author={Thomas R. Cimato and Beth A. Palka and Jennifer K Lang and Rebeccah F. Young},
  booktitle={PloS one},
  year={2013}
}
BACKGROUND Hypercholesterolemia plays a critical role in atherosclerosis. CD34+ CD45dim Lineage- hematopoietic stem/progenitor cells (HSPCs) give rise to the inflammatory cells linked to atherosclerosis. In mice, high cholesterol levels mobilize HSPCs into the bloodstream, and promote their differentiation to granulocytes and monocytes. The objective of our study was to determine how cholesterol levels affect HSPC quantity in humans. METHODS We performed a blinded, randomized hypothesis… CONTINUE READING
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