LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells.

  title={LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells.},
  author={Almut Brand and Katrin Singer and Gudrun E. Koehl and Marlene Kolitzus and Gabriele Schoenhammer and Annette Thiel and Carina Matos and Christina Bruss and Sebastian Klobuch and Katrin Peter and Michael Kastenberger and Christian Bogdan and Ulrike Schleicher and Andreas Mackensen and Evelyn Ullrich and Stefan Fichtner-Feigl and Rebecca K Kesselring and Matthias Mack and Uwe Ritter and Maximilian Schmid and Christian U Blank and Katja Dettmer and Peter J. Oefner and Petra Hoffmann and Stefan Walenta and Edward Kenneth Geissler and Jacques M. Pouyssegur and Andreas Villunger and Andr{\'e} Steven and Barbara Seliger and S Schreml and Sebastian Haferkamp and Elisabeth A Kohl and Sigrid Karrer and Mark Berneburg and Wolfgang Herr and Wolfgang F Mueller-Klieser and Kathrin Renner and Marina P. Kreutz},
  journal={Cell metabolism},
  volume={24 5},
Elevated lactate dehydrogenase A (LDHA) expression is associated with poor outcome in tumor patients. Here we show that LDHA-associated lactic acid accumulation in melanomas inhibits tumor surveillance by T and NK cells. In immunocompetent C57BL/6 mice, tumors with reduced lactic acid production (Ldhalow) developed significantly slower than control tumors and showed increased infiltration with IFN-γ-producing T and NK cells. However, in Rag2-/-γc-/- mice, lacking lymphocytes and NK cells, and… CONTINUE READING
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