LC determination and pharmacokinetics of meloxicam.

  title={LC determination and pharmacokinetics of meloxicam.},
  author={Bhavesh Dasandi and Shivaprakash and H Saroj and K. Mahalingeswara Bhat},
  journal={Journal of pharmaceutical and biomedical analysis},
  volume={28 5},
A simple and rapid HPLC assay method for the estimation of meloxicam in plasma was developed. The method totally eliminated the solvent extraction procedure. The plasma proteins were precipitated using perchloric acid (70%) and acetonitrile mixture (1:1 v/v) and the supernatant was directly injected to the HPLC system. The separation was achieved on a Lichrospher C18 5 micron (125x4.0 mm) analytical column with a mobile phase of sodium acetate buffer (pH 3.3, 170 mmol):acetonitrile (62:38 v/v… CONTINUE READING

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