LC-MS-based serum metabolomic analysis reveals dysregulation of phosphatidylcholines in esophageal squamous cell carcinoma.

@article{Mir2015LCMSbasedSM,
  title={LC-MS-based serum metabolomic analysis reveals dysregulation of phosphatidylcholines in esophageal squamous cell carcinoma.},
  author={Sartaj Ahmad Mir and Pavithra Rajagopalan and Ankit P. Jain and Aafaque Ahmad Khan and Keshava K. Datta and Sonali V Mohan and Syed Salman Lateef and Nandini A. Sahasrabuddhe and Babu Lal Somani and T S Keshava Prasad and Aditi Chatterjee and Kariyanakatte Veeraiah Veerendra Kumar and Manavalan Vijayakumar and Rekha Vijay Kumar and Seetaramanjaneyulu Gundimeda and Akhilesh Pandey and Harsha Gowda},
  journal={Journal of proteomics},
  year={2015},
  volume={127 Pt A},
  pages={96-102}
}
UNLABELLED Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive cancers with poor prognosis. Here, we carried out liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-Q-TOF-MS)-based untargeted metabolomic analysis of ESCC serum samples. Statistical analysis resulted in the identification of 652 significantly dysregulated molecular features in serum from ESCC patients as compared to the healthy subjects. Phosphatidylcholines were identified as a major class… CONTINUE READING