LC-MS based quantification of 2'-ribosylated nucleosides Ar(p) and Gr(p) in tRNA.


RNA nucleosides are often naturally modified into complex non-canonical structures with key biological functions. Here we report LC-MS quantification of the Ar(p) and Gr(p) 2'-ribosylated nucleosides in tRNA using deuterium labelled standards, and the first detection of Gr(p) in complex fungi. 
DOI: 10.1039/c1cc11011j


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