Corpus ID: 100778312

LC-MS-MS method determination of beraprost in human plasma

  title={LC-MS-MS method determination of beraprost in human plasma},
  author={Tan Zhi-rong},
  journal={Central South Pharmacy},
Objective To establish an LC-MS-MS method for the determination of beraprost in human plasma.Methods Beraprost in plasma samples was extracted with 5 mL diethyl ether / chloroform(3∶1,v/v).The analysis involved a Hypurity C18(150 mm × 2.1 mm,5 μm) column.The mobile phase consisted of acetonitrile:water(1 000 mL water added 2 mL formic acid) =(80∶20),the flow rate was 0.2 mL·min-1,and the column temperature was 40 ℃.Mass spectrum conditions:Caplillary voltage: 3.0 kV;Source Temp: 100… Expand
1 Citations
Study on bioequivalence of beraprost in healthy volunteers by liquid chromatography with tandem mass spectrometry.
A liquid chromatography tandem mass spectrometry method developed for the quantification of beraprost in human plasma with high sensitivity at picogram per milliliter concentration was applied successfully to a bioequivalence study and showed that the two formulations of berAProst are bioequivalent. Expand