LC-MS/MS quantitative analysis of paclitaxel and its major metabolites in serum, plasma and tissue from women with ovarian cancer after intraperitoneal chemotherapy.

Abstract

A method for determination of the antineoplastic drug paclitaxel and its main metabolites (viz. 6α-hydroxypaclitaxel and p-3'-hydroxypaclitaxel) at the sub-ng/ml level is here presented. Sample preparation consisted of a liquid-liquid extraction step for cleanup and preconcentration of the target analytes prior to chromatographic analysis by tandem mass… (More)
DOI: 10.1016/j.jpba.2013.12.028

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@article{FernndezPeralbo2014LCMSMSQA, title={LC-MS/MS quantitative analysis of paclitaxel and its major metabolites in serum, plasma and tissue from women with ovarian cancer after intraperitoneal chemotherapy.}, author={Mar{\'i}a A. Fern{\'a}ndez-Peralbo and Feliciano Priego-Capote and Mar{\'i}a D Luque de Castro and {\'A}ngela Casado-Adam and {\'A}lvaro Arjona-S{\'a}nchez and Francisco Crist{\'o}bal Mu{\~n}oz-Casares}, journal={Journal of pharmaceutical and biomedical analysis}, year={2014}, volume={91}, pages={131-7} }