LC-MS/MS method for confirmation of recombinant human erythropoietin and darbepoetin alpha in equine plasma.

@article{Guan2007LCMSMSMF,
  title={LC-MS/MS method for confirmation of recombinant human erythropoietin and darbepoetin alpha in equine plasma.},
  author={Fuyu Guan and Cornelius E. Uboh and Lawrence R Soma and Eric K. Birks and Jinwen Chen and Janis Mitchell and Youwen You and Jeffrey A Rudy and Fran Xu and Xiaoqing Li and Gustave N K Mbuy},
  journal={Analytical chemistry},
  year={2007},
  volume={79 12},
  pages={4627-35}
}
Recombinant human erythropoietin (rhEPO) and darbepoetin alpha (DPO) are protein-based drugs for the treatment of anemia by stimulating red blood cell production. Consequently, they are abused in human and equine sports. To deter their abuse in the horse racing industry, a sensitive and reliable method for confirmation of these agents in equine plasma has been in urgent need. Such a method by LC-MS/MS is described in this paper. The method involved analyte enrichment by immunoaffinity… CONTINUE READING
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