LC-MS/MS determination of the HIV-1 protease inhibitor indinavir in brain and testis of mice.

Abstract

A rapid and sensitive method for the determination of indinavir in mice brain and testis is described and validation data are provided. Indinavir and the internal standard (IS) amprenavir were isolated from homogenized tissue matrices using a mixed-mode solid-phase extraction (SPE) procedure and were then analyzed by reversed-phase liquid chromatography… (More)

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@article{Oliveira2006LCMSMSDO, title={LC-MS/MS determination of the HIV-1 protease inhibitor indinavir in brain and testis of mice.}, author={Manuela Pereira de Oliveira and Nicolas Venisse and William Couet and Jean-Christophe Olivier}, journal={Journal of pharmaceutical and biomedical analysis}, year={2006}, volume={40 2}, pages={353-9} }