Corpus ID: 101271948

LC-MS/MS determination of flunarizine in human plasma and application in bioequivalence evaluation

@article{Yao2011LCMSMSDO,
  title={LC-MS/MS determination of flunarizine in human plasma and application in bioequivalence evaluation},
  author={Cheng Yao and Tan Zhi-rong and Wang Yi-cheng and Li Hui and Li Ling and Deng Xiao-Lan and Zhang Wei and Zhou Hong-hao},
  journal={Chinese Journal of Clinical Pharmacology and Therapeutics},
  year={2011},
  volume={16},
  pages={400}
}
AIM: To establish a LC-MS/MS method for determination of flunarizine in human plasma,and to study the relative bioequivalence of flunarizine hydrochloride made by Yangtze River Pharmaceutical Group Co.,Ltd. METHODS: Thermo Hypurity C18 column(150 mm×2.1 mm,5 μm) was used in the experiment.Acetonitrile-10 mmol/L ammonium formate(including 0.1% formic acid)(65∶35,V/V) was used as mobile phase and the flow rate was 0.3 mL/min and the injection volume was 10 μL.The column temperature was set at 40… Expand
1 Citations
A high-throughput LC-MS/MS method for determination of flunarizine in human plasma: Pharmacokinetic study with different doses.
TLDR
The LC-MS/MS method was used to evaluate the pharmacokinetics of 5 and 10 mg flunarizine tablet formulation in 24 healthy subjects and the drug was stable in human plasma under all tested conditions. Expand