LBP inhibitory peptide reduces endotoxin-induced macrophage activation and mortality

@article{Wu2005LBPIP,
  title={LBP inhibitory peptide reduces endotoxin-induced macrophage activation and mortality},
  author={Xiaoqin Wu and Gui-sheng Qian and Ying Zhao and Dawei Xu},
  journal={Inflammation Research},
  year={2005},
  volume={54},
  pages={451-457}
}
Objective and Design: The aim of this study was to investigate whether P12, a lipopolysaccharide (LPS)-binding protein (LBP) inhibitory peptide could reduce LPS induced inflammation in vitro and in vivo. Material and Methods: Human monocyte-like cell line (U937 cells) was grown in RPMI 1640 and stimulated with PMA in order to induce differentiation to the macrophage stage. A total of 70 Kunming mice (8–12 wk old) were used in our experiments. The effects of P12 on the binding of LPS to U937… CONTINUE READING