LAZ3 rearrangements in non-Hodgkin's lymphoma: correlation with histology, immunophenotype, karyotype, and clinical outcome in 217 patients.

@article{Bastard1994LAZ3RI,
  title={LAZ3 rearrangements in non-Hodgkin's lymphoma: correlation with histology, immunophenotype, karyotype, and clinical outcome in 217 patients.},
  author={Christian Bastard and Clotilde Deweindt and Jean Pierre Kerckaert and Bernard Lenormand and Andrea Rossi and Francesco Pezzella and Christophe Fruchart and Christian Duval and Mathieu Monconduit and Herv{\'e} Tilly},
  journal={Blood},
  year={1994},
  volume={83 9},
  pages={2423-7}
}
We have recently shown that an evolutionary conserved gene LAZ3, encoding a zinc finger protein, is disrupted and overexpressed in some B-cell lymphomas (mainly with a large cell component) that show chromosomal rearrangements involving 3q27. Because the breakpoints involved in these rearrangements are focused in a narrow major translocation cluster (MTC) on chromosome 3, we used genomic probes from this region to study the molecular rearrangements of LAZ3 in a large series of patients (217… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 25 references

Cloning of a breakpoint cluster region at band 3q27 in human non-Hodgkin’s lymphoma

  • C Deweindt, J PKerckaert, H Tilly, S Quief, VC Nguyen, C Bastard
  • Genes Chrom Cancer
  • 1993

LAB, a novel zinc-finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomas

  • C tard
  • Nature Genet
  • 1993

RSK: BCL-6 rearrangement defines a clinical and prognostic subset of diffuse large cell lymphoma

  • F Lo Coco, D Louie, +5 authors Chaganti
  • Blood 82:133a,
  • 1993

BCL - 6 rearrangement defines a clinical and prognostic subset of diffuse large cell lymphoma

  • K Offit, F LoCoco, +6 authors Chaganti RSK
  • Blood
  • 1992

Identification of the gene associated with the recurring chromosomal translocations t ( 3 ; 14 ) ( q 27 ; q 32 ) and t ( 3 ; 22 ) ( q 27 ; qll ) in B - cell lymphomas

  • B Baron, G Nucifora, N McCabe, R Espinosa, MM LeBeau, TW McKeithan
  • Roc Natl Acad Sci USA
  • 1992

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