LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation.

@article{Zhang1998LATPI,
  title={LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation.},
  author={W. Zhang and Ronald P. Trible and Lawrence E. Samelson},
  journal={Immunity},
  year={1998},
  volume={9 2},
  pages={
          239-46
        }
}
The linker molecule LAT is a critical substrate of the tyrosine kinases activated upon TCR engagement. Phosphorylated LAT binds Grb2, PLC-gamma1, and other signaling molecules. We demonstrate that human LAT is palmitoylated and that palmitoylated LAT predominantly localizes into glycolipid-enriched microdomains (GEMs). Although the LAT transmembrane domain is sufficient for membrane localization, palmitoylation at C26 and C29 is essential for efficient partitioning into GEMs. LAT palmitoylation… Expand
Palmitoylation of LAT contributes to its subcellular localization and stability.
TLDR
It is suggested that palmitoylation has an important role in trafficking to the plasma membrane and the stability of LAT, an adaptor molecule mediating T cell receptor signaling, which is unable to localize in lipid rafts and to mediate T cell activation. Expand
Localization of LAT in Glycolipid-enriched Microdomains Is Required for T cell Activation*
TLDR
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Palmitoylation-Dependent Plasma Membrane Transport but Lipid Raft-Independent Signaling by Linker for Activation of T Cells1
TLDR
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TLDR
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TLDR
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TLDR
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The membrane proximal proline-rich region and correct order of C-terminal tyrosines on the adaptor protein LAT are required for TCR-mediated signaling and downstream functions.
TLDR
It is observed that the membrane proximal, proline-rich region of LAT and the correct order of domains containing conserved tyrosines are necessary for optimal TCR-mediated early signaling, cytokine production, and cellular adhesion. Expand
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TLDR
Two recently identified adaptor proteins, TRIM (T cell receptor interacting molecule) and SIT (SHP2-interacting transmembrane adaptor protein), which constitutively associate with several surface molecules, bind to PI3K and SHP2, respectively, after T cell activation and might also function in the TCR signalling pathway. Expand
The role of membrane rafts in Lck transport, regulation and signalling in T-cells.
TLDR
The present review discusses the signals that target Lck to membrane rafts and the importance of these specialized membranes in the transport of Lk to the plasma membrane, the regulation of Lck activity and the phosphorylation of the TCR. Expand
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