LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway.

@article{Finco1998LATIR,
  title={LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway.},
  author={T S Finco and Theresa A. Kadlecek and Wei Zhang and Lawrence E Samelson and Arthur Weiss},
  journal={Immunity},
  year={1998},
  volume={9 5},
  pages={617-26}
}
In this study, we present the further characterization of a mutant Jurkat T cell line, J.CaM2, that is defective in TCR-mediated signal transduction. Although initial TCR-mediated signaling events such as the inducible tyrosine phosphorylation of the TCR-zeta chain and ZAP-70 are intact in J.CaM2, subsequent events, including increases in intracellular calcium, Ras activation, and IL-2 gene expression are defective. Subsequent analysis of J.CaM2 demonstrated a severe deficiency in pp36/LAT… CONTINUE READING
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