LARP-1 promotes oogenesis by repressing fem-3 in the C. elegans germline.

  title={LARP-1 promotes oogenesis by repressing fem-3 in the C. elegans germline.},
  author={Esther Zanin and Anne Pacquelet and Claudia Scheckel and Rafal Ciosk and Monica Gotta},
  journal={Journal of cell science},
  volume={123 Pt 16},
LA-related protein 1 (LARP-1) belongs to an RNA-binding protein family containing a LA motif. Here, we identify LARP-1 as a regulator of sex determination. In C. elegans hermaphrodites, a complex regulatory network regulates the switch from sperm to oocyte production. We find that simultaneous depletion of larp-1 and the Nanos homologue nos-3 results in germline masculinization. This phenotype is accompanied by a strong reduction of the levels of TRA-1, a GLI-family transcription factor that… CONTINUE READING
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