LARGE2 facilitates the maturation of alpha-dystroglycan more effectively than LARGE.

@article{Fujimura2005LARGE2FT,
  title={LARGE2 facilitates the maturation of alpha-dystroglycan more effectively than LARGE.},
  author={Katsuya Fujimura and Hiromichi Sawaki and Tokiko Sakai and Toru Hiruma and Nobuo Nakanishi and Takashi Sato and Takashi Ohkura and Hisashi Narimatsu},
  journal={Biochemical and biophysical research communications},
  year={2005},
  volume={329 3},
  pages={1162-71}
}
The LARGE gene is thought to encode a putative glycosyltransferase because of its typical topology. However, no enzyme activity has been demonstrated yet, although the gene apparently supports the functional maturation of alpha-dystroglycan by glycosylation when it is transfected into cells. A novel homologous gene to LARGE was identified and named LARGE2. LARGE2 recombinant was co-expressed with alpha-dystroglycan in human embryonic kidney 293T cells to determine its activity to support the… CONTINUE READING
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