LAG-3, a novel lymphocyte activation gene closely related to CD4

  title={LAG-3, a novel lymphocyte activation gene closely related to CD4},
  author={Fr{\'e}d{\'e}ric Triebel and Setsuko Jitsukawa and Elena Baixeras and Sergio Rom{\'a}n-Rom{\'a}n and C Genev{\'e}e and Evani M Viegas-P{\'e}quignot and Thierry Hercend},
  journal={The Journal of Experimental Medicine},
  pages={1393 - 1405}
We have identified a novel human gene of the Ig superfamily, designated LAG-3. Expression of this gene is undetectable in resting PBL, while it is found (a 2-kb message) in activated T and NK cells. The LAG-3 gene includes eight exons; the corresponding cDNA encodes a 498-amino acid membrane protein with four extracellular IgSF domains. The first one belongs to the V-SET; it is particular since it includes an extra loop in the middle of the domain and an unusual intrachain disulphide bridge… CONTINUE READING


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