LAD syndromes: FERMT3 kindles the signal.

Abstract

LAD syndromes are uncommon but important genetic disorders of host defense. In this issue of Blood, Kuijpers and colleagues now report that one of them, LAD-I variant (LAD-Iv; also called LAD-III), is caused by mutations in FERMT3, a gene that encodes an intracellular protein that interacts with cytoplasmic tails of integrin chains in hematopoetic cells… (More)
DOI: 10.1182/blood-2009-01-198853

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