LAD syndromes: FERMT3 kindles the signal.


LAD syndromes are uncommon but important genetic disorders of host defense. In this issue of Blood, Kuijpers and colleagues now report that one of them, LAD-I variant (LAD-Iv; also called LAD-III), is caused by mutations in FERMT3, a gene that encodes an intracellular protein that interacts with cytoplasmic tails of integrin chains in hematopoetic cells… (More)
DOI: 10.1182/blood-2009-01-198853


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