LACK OF ENHANCEMENT OF DIMETHYLTRYPTAMINE FORMATION IN RAT BRAIN AND RABBIT LUNG IN VIVO BY METHIONINE OR S‐ADENOSYLMETHIONINE

@article{Stramentinoli1978LACKOE,
  title={LACK OF ENHANCEMENT OF DIMETHYLTRYPTAMINE FORMATION IN RAT BRAIN AND RABBIT LUNG IN VIVO BY METHIONINE OR S‐ADENOSYLMETHIONINE},
  author={Giorgio Stramentinoli and Ross J. Baldessarini},
  journal={Journal of Neurochemistry},
  year={1978},
  volume={31}
}
In vivo conversion of intracisternally administered [14C]tryptamine to [14C]N,N‐dimethyl‐tryptamine (DMT) in rat brain, even in the presence of an excess of substrate and methyl donor appeared to be insignificant, although enzymatically synthesized [14C]DMT was recovered readily after intracranial injection. Authenticity of [14C]DMT was demonstrated by cocrystallization with authentic DMT and oxalic acid to constant specific radioactivity after chromatographic separation of [14C]DMT. In rabbit… Expand
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