L41Q polymorphism of the G protein coupled receptor kinase 5 is associated with left ventricular apical ballooning syndrome

  title={L41Q polymorphism of the G protein coupled receptor kinase 5 is associated with left ventricular apical ballooning syndrome},
  author={Letizia Spinelli and Valentina Trimarco and Serena Di Marino and Marina Marino and Guido Iaccarino and Bruno Trimarco},
  journal={European Journal of Heart Failure},
Altered response to acute catecholamine increase in the synaptic cleft is considered to be the mechanism underlying transient left ventricular apical ballooning syndrome (LVABS). –3 Cardiac adrenergic receptors (ARs) of the b1 and b2 subtypes activate myocytes by coupling to the Ga subunit of the heterotrimeric Gs protein, but on the other hand they also promote G protein coupled receptor kinase (GRK)-mediated phosphorylation of bAR with the intent to shut-off signalling. The impact on cardiac… 

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