L1210(A) mouse lymphoma cells depleted of glutathione with L-buthionine-S-R-sulfoximine proliferate in tissue culture.

@article{Gaetjens1984L1210AML,
  title={L1210(A) mouse lymphoma cells depleted of glutathione with L-buthionine-S-R-sulfoximine proliferate in tissue culture.},
  author={Eric Gaetjens and Philip C. Chen and John D. Broome},
  journal={Biochemical and biophysical research communications},
  year={1984},
  volume={123 2},
  pages={626-32}
}
L1210(A) mouse lymphoma cells have been adapted to long-term tissue culture in the presence of L-buthionine-S-R-sulfoximine in concentrations of 1-10 mM. As a result of the inhibitory action of this compound on the synthesis of gamma-glutamylcysteine, the dipeptide precursor of glutathione, the cells are depleted of more than 90% of their normal cellular… CONTINUE READING