L1 knockout mice show dilated ventricles, vermis hypoplasia and impaired exploration patterns.

@article{Fransn1998L1KM,
  title={L1 knockout mice show dilated ventricles, vermis hypoplasia and impaired exploration patterns.},
  author={Erik Frans{\'e}n and Rudi D'hooge and Guy Van Camp and Marleen Verhoye and Jan Sijbers and Edwin Reyniers and Philippe Soriano and Hiroyuki Kamiguchi and Rob Willemsen and Sebastiaan K. E. Koekkoek and Chris I De Zeeuw and Peter Paul De Deyn and A Van der Linden and Vance P. Lemmon and R. Frank Kooy and Patrick J. Willems},
  journal={Human molecular genetics},
  year={1998},
  volume={7 6},
  pages={999-1009}
}
L1 is a neural cell adhesion molecule mainly involved in axon guidance and neuronal migration during brain development. Mutations in the human L1 gene give rise to a complex clinical picture, with mental retardation, neurologic abnormalities and a variable degree of hydrocephalus. Recently, a transgenic mouse model with a targeted null mutation in the L1 gene was generated. These knockout (KO) mice show hypoplasia of the corticospinal tract. Here we have performed further studies of these KO… CONTINUE READING
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