L1 Mosaicism in Mammals: Extent, Effects, and Evolution.

@article{Faulkner2017L1MI,
  title={L1 Mosaicism in Mammals: Extent, Effects, and Evolution.},
  author={Geoffrey J. Faulkner and Jose Luis Garc{\'i}a-P{\'e}rez},
  journal={Trends in genetics : TIG},
  year={2017},
  volume={33 11},
  pages={802-816}
}
The retrotransposon LINE-1 (long interspersed element 1, L1) is a transposable element that has extensively colonized the mammalian germline. L1 retrotransposition can also occur in somatic cells, causing genomic mosaicism, as well as in cancer. However, the extent of L1-driven mosaicism arising during ontogenesis is unclear. We discuss here recent experimental data which, at a minimum, fully substantiate L1 mosaicism in early embryonic development and neural cells, including post-mitotic… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 31 times. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 153 references

Intact piRNA pathway prevents L1 mobilization in male meiosis.

Proceedings of the National Academy of Sciences of the United States of America • 2017

Similar Papers

Loading similar papers…