L1 Mosaicism in Mammals: Extent, Effects, and Evolution.

  title={L1 Mosaicism in Mammals: Extent, Effects, and Evolution.},
  author={Geoffrey J. Faulkner and Jose Luis Garc{\'i}a-P{\'e}rez},
  journal={Trends in genetics : TIG},
  volume={33 11},
The retrotransposon LINE-1 (long interspersed element 1, L1) is a transposable element that has extensively colonized the mammalian germline. L1 retrotransposition can also occur in somatic cells, causing genomic mosaicism, as well as in cancer. However, the extent of L1-driven mosaicism arising during ontogenesis is unclear. We discuss here recent experimental data which, at a minimum, fully substantiate L1 mosaicism in early embryonic development and neural cells, including post-mitotic… CONTINUE READING
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Proceedings of the National Academy of Sciences of the United States of America • 2017

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