L1-CAM in cancerous tissues.

  title={L1-CAM in cancerous tissues.},
  author={Nancy Gavert and Amir Ben-Shmuel and Shani Raveh and Avri Ben-Ze'ev},
  journal={Expert opinion on biological therapy},
  volume={8 11},
BACKGROUND L1-cell adhesion molecule (L1-CAM) is a cell adhesion receptor of the immunoglobulin superfamily, known for its roles in nerve cell function. While originally believed to be present only in brain cells, in recent years L1-CAM has been detected in other tissues, and in a variety of cancer cells, including some common types of human cancer. OBJECTIVE/METHODS We review the prevalence of L1-CAM in human cancer, the possible mechanisms involved in L1-CAM-mediated tumorigenesis, and… CONTINUE READING


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