L. monocytogenes-induced actin assembly requires the actA gene product, a surface protein.

@article{Kocks1992LMA,
  title={L. monocytogenes-induced actin assembly requires the actA gene product, a surface protein.},
  author={Christine Kocks and Edith Gouin and Marc Tabouret and Patrick Berche and H{\'e}l{\`e}ne Ohayon and Pascale Cossart},
  journal={Cell},
  year={1992},
  volume={68 3},
  pages={521-31}
}
The intracellular pathogenic bacterium L. monocytogenes can spread directly from cell to cell without leaving the cytoplasm. The mechanism of this movement, generated through bacterially induced actin polymerization, is not understood. By analyzing an avirulent Tn917-lac mutant defective for actin polymerization, we have identified a bacterial component involved in this process. The transposon had inserted in actA, the second gene of an operon. Gene disruption of downstream genes and… CONTINUE READING

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