L-tyrosine contributes to (+)-3,4-methylenedioxymethamphetamine-induced serotonin depletions.

@article{Breier2006LtyrosineCT,
  title={L-tyrosine contributes to (+)-3,4-methylenedioxymethamphetamine-induced serotonin depletions.},
  author={Joseph M Breier and Michael G Bankson and Bryan K. Yamamoto},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2006},
  volume={26 1},
  pages={
          290-9
        }
}
  • Joseph M Breier, Michael G Bankson, Bryan K. Yamamoto
  • Published in
    The Journal of neuroscience…
    2006
  • Biology, Medicine
  • The specific mechanisms underlying (+)-3,4-methylenedioxymethamphetamine (MDMA)-induced damage to 5-HT terminals are unknown. Despite the hypothesized role for dopamine (DA) and DA-derived free radicals in mediating this damage, it remains unclear why MDMA produces long-term depletions of 5-HT in brain regions that are sparsely innervated by DA neurons. We hypothesized that the precursor to DA biosynthesis, tyrosine, mediates MDMA-induced 5-HT depletions. Extracellular tyrosine concentrations… CONTINUE READING

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