L-type calcium channels in the hippocampus and cerebellum of Alzheimer's disease brain tissue.

@article{Coon1999LtypeCC,
  title={L-type calcium channels in the hippocampus and cerebellum of Alzheimer's disease brain tissue.},
  author={Alex L. Coon and David W. Wallace and Charles F. Mactutus and Rosemarie M Booze},
  journal={Neurobiology of aging},
  year={1999},
  volume={20 6},
  pages={597-603}
}
There is growing evidence that the selective neuronal cell death observed in Alzheimer's Disease (AD) is the result of dysregulation of intracellular calcium (Ca2+) homeostasis. In the present study, L-type voltage sensitive calcium channels (L-VSCCs) were examined in the cerebellum and hippocampus of AD (n = 6; postmortem interval less than 5 h) and age-matched control (n = 6) tissue by homogenate binding techniques and quantitative in vitro receptor autoradiography using [3H]isradipine (PN200… CONTINUE READING