L-type amino acid transporter 1 utilizing prodrugs: How to achieve effective brain delivery and low systemic exposure of drugs.

@article{Puris2017LtypeAA,
  title={L-type amino acid transporter 1 utilizing prodrugs: How to achieve effective brain delivery and low systemic exposure of drugs.},
  author={Elena Puris and Mikko Gynther and Johanna Huttunen and Aleksanteri Petsalo and Kristiina M Huttunen},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2017},
  volume={261},
  pages={
          93-104
        }
}
L-type amino acid transporter 1 (LAT1) is selectively expressed in the blood-brain barrier (BBB) and brain parenchyma. This transporter can facilitate brain delivery of neuroprotective agents and additionally give opportunity to minimize systemic exposure. Here, we investigated structure-pharmacokinetics relationship of five newly synthesized LAT1-utilizing prodrugs of the cyclooxygenase inhibitor, ketoprofen, in order to identify beneficial structural features of prodrugs to achieve both… CONTINUE READING
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