L-type Calcium Current (ICa,L) and Inward Rectifier Potassium Current (IK1) are Involved in QT Prolongation Induced by Arsenic Trioxide in Rat

  title={L-type Calcium Current (ICa,L) and Inward Rectifier Potassium Current (IK1) are Involved in QT Prolongation Induced by Arsenic Trioxide in Rat},
  author={Xichuang Chen and Hongli Shan and Jinlong Zhao and Yuan Hong and Yunlong Bai and Iihua Sun and Zhenwei Pan and Yong Zhang and Baofeng Yang and Zhimin Du},
  journal={Cellular Physiology and Biochemistry},
  pages={967 - 974}
The present study was designed to study the effects of As<sub>2</sub>O<sub>3</sub> on QT interval prolongation and to explore the potential ionic mechanisms in isolated rat ventricular cardiomyocytes. The rats of As<sub>2</sub>O<sub>3</sub> group were treated with 0.8 mg·kg<sup>-1</sup>·d<sup>-1</sup> As<sub>2</sub>O<sub>3</sub> intravenously for 7 days consecutively and the control group with saline. The ECG was recorded to calculate heart rate-corrected QT interval (QTc). Single… 

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