L-type Ca2+ current in guinea pig ventricular myocytes treated with modulators of tyrosine phosphorylation.

@article{Ogura1999LtypeCC,
  title={L-type Ca2+ current in guinea pig ventricular myocytes treated with modulators of tyrosine phosphorylation.},
  author={T Ogura and Lesya M. Shuba and T F McDonald},
  journal={The American journal of physiology},
  year={1999},
  volume={276 5 Pt 2},
  pages={H1724-33}
}
  • T Ogura, Lesya M. Shuba, T F McDonald
  • Published 1999 in The American journal of physiology
Guinea pig ventricular myocytes in whole cell configuration were treated with tyrosine kinase (TK) inhibitors [genistein (Gst), tyrphostin A23 (T23), and tyrphostin A25 (T25)] and with inactive analogs [daidzein, genistin, and tyrphostin A1 (T1)] to measure effects on L-type Ca2+ current (ICa,L). Gst inhibited ICa,L (IC50 = 47 microM) without affecting its time course or shifting the ICa, L-voltage relationship. At the highest concentration of isoflavone tested (200 microM), ICa,L was inhibited… CONTINUE READING