L-type Ca2+ channels in fetal and adult ovine cerebral arteries.

  title={L-type Ca2+ channels in fetal and adult ovine cerebral arteries.},
  author={Arlin B. Blood and Yu Zhao and Wen Long and Lubo Zhang and Lawrence D. Longo},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  volume={282 1},
Recently, we reported that, whereas in cerebral arteries of the adult a majority of norepinephrine (NE)-induced increase in intracellular Ca2+ concentration ([Ca2+]i) comes from release of the sarcoplasmic reticulum (SR) Ca2+ stores, in the fetus the SR Ca2+ stores are relatively small, and NE-induced increase in [Ca2+]i results mainly from activation of plasma membrane L-type Ca2+ channels (20). In an effort to establish further the role of L-type Ca2+ channels in the developing cerebral… CONTINUE READING
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