L-type Ca2+ channel-insulin-like growth factor-1 receptor signaling impairment in aging rat skeletal muscle.

@article{Renganathan1997LtypeCC,
  title={L-type Ca2+ channel-insulin-like growth factor-1 receptor signaling impairment in aging rat skeletal muscle.},
  author={Muthukrishnan Renganathan and William Edmund Sonntag and Osvaldo Delbono},
  journal={Biochemical and biophysical research communications},
  year={1997},
  volume={235 3},
  pages={784-9}
}
The present study investigates the modulation of skeletal muscle L-type Ca2+ channel receptor in response to insulin-like growth factor-1 receptor (IGF-1R) activation. Single extensor digitorum longus and multifiber preparations were isolated from 7- (young), 14- (middle-age) and 28-(old) month- Fisher 344 X Brown Norway rats. Calcium current was potentiated in fibers from young and middle-age rats due to a -13 mV shift in half-activation potential. Fibers from old animals failed to show… CONTINUE READING