L-type Ca2+ channel function and expression in neonatal rabbit ventricular myocytes.

@article{Huang2006LtypeCC,
  title={L-type Ca2+ channel function and expression in neonatal rabbit ventricular myocytes.},
  author={Jingbo Huang and Liqun Xu and Marion Y. Thomas and Keith W. Whitaker and Leif Hove-Madsen and Glen F. Tibbits},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2006},
  volume={290 6},
  pages={
          H2267-76
        }
}
L-type Ca(2+) channel-mediated, Ca(2+)-induced Ca(2+) release (CICR) is the dominant mode of excitation-contraction (E-C) coupling in the mature mammalian myocardium but is thought to be absent in the fetal and newborn mammalian myocardium. Furthermore, the characteristics and contributors of E-C coupling at the earliest developmental stages are poorly understood. In this study, we measured [(3)H](+)PN200-110 dihydropyridine binding capacity, functionality and expression of the L-type Ca(2… CONTINUE READING

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