L-thiocitrulline. A stereospecific, heme-binding inhibitor of nitric-oxide synthases.

  title={L-thiocitrulline. A stereospecific, heme-binding inhibitor of nitric-oxide synthases.},
  author={Christa Frey and Kuthirummal Narayanan and Kirk McMillan and Lionel Spack and Steven S. Gross and Bettie Sue Siler Masters and Owen W. Griffith},
  journal={The Journal of biological chemistry},
  volume={269 42},
Nitric-oxide synthase (NOS) catalyzes the oxidation of L-arginine to citrulline and nitric oxide (NO). The enzyme is inhibited by a variety of N omega-monosubstituted L-arginine analogs, and some of these compounds are useful in reversing pathologies associated with the overproduction of NO (e.g. the hypotension of septic shock). We report here that L-thiocitrulline (gamma-thioureido-L-norvaline) is a potent, stereospecific inhibitor of the constitutive brain and endothelial isoforms of NOS as… CONTINUE READING


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